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Top 10 stories of 2007


 

December 2007

Every year, the Infectious Disease News Editorial Advisory Board votes on what they think are the most significant stories of the year. The following are their picks, in order of votes garnered. Think we missed any? E-mail us at IDN@slackinc.com and tell us your thoughts.

— Jay Lewis, Managing Editor.


1. Nationwide study reveals MRSA more widespread than previously believed

 

Electron micrograph depicting a grouping of MRSA bacteria
Electron micrograph depicting a grouping of methicillin resistant Staphylococcus aureus (MRSA) bacteria

 

Source: CDC

Although MRSA infections have been considered a significant public health problem for several years, a recently-published study revealed that they may be more common than doctors previously understood. The study also indicated that although MRSA infections remain primarily health care-associated, they are increasingly being seen in other settings.

2. Yale study: Universal HIV screening is cost-effective

In 2006, the CDC recommended routine volunteer HIV testing for all Americans aged 13 to 64. Earlier this year, a Yale study demonstrated that such an approach to HIV testing is cost-effective. The Yale study confirmed that universal HIV testing is cost-effective even in places where the percentage of patients with HIV is low and patients may not meet the criteria for traditional risk factors.

3. Rates of XDR-TB, MDR-TB increasing

Multidrug-resistant TB is now present in 90 countries and extensively drug-resistant TB is becoming more prevalent in countries throughout the world. According to WHO estimates, 423,000 new cases of MDR-TB occur each year. For most patients with TB throughout the world, proper diagnosis and treatment remain inadequate.

4. Study in Kenya and Uganda finds male circumcision significantly reduces HIV risk

The study found that male circumcision was associated with up to a 50% reduction in the risk of contracting HIV. The study, which was stopped early due to clear efficacy, prompted WHO to recommend circumcision as an additional intervention to reduce the risk of HIV transmission.

5. Merck discontinues HIV vaccine candidate

A phase-2 clinical trial of V520, an investigational HIV vaccine, was discontinued earlier this year. Following a review of safety data and interim efficacy analysis, the Independent Data Safety Monitoring Board said the vaccine would not meet its primary endpoints and recommended the discontinuation of the trial.

6. Human-to-human transmission of avian influenza detected

Researchers discovered what they believe is the first evidenceof human-to-humantransmission of H5N1. The transmission occurred among an extended family in Indonesia.

7. Increased number of foodborne illness outbreaks reported

Foodborne illness outbreaks – including E. Coli, botulism and salmonella – were reported with increasing frequency this year. Experts have questioned the safety of the food supply and public health officials have urged tighter restrictions to reduce the risk of foodborne illness outbreaks.

8. Two new studies find contrasting views of influenza vaccine effectiveness

A study published in the Oct. 7 issue of Lancet Infectious Diseases questioned the notion that influenza immunization saves lives in the elderly population. But another study, published in The New England Journal of Medicine, demonstrated that influenza vaccines reduced mortality from influenza complications in the elderly by 48%.

9. Chikungunya fever outbreak reported in Italy

In September, Italian health officials reported 254 cases of Chikungunya fever. The outbreak occurred in the province of Ravenna, in Italy’s Emilia-Romagna region. Public health officials said they believed this was the first outbreak of Chikungunya fever in Europe. Previously, outbreaks have typically been reported in Africa and Asia.

10. ACIP recommends MCV4 for adolescents

In an effort to simplify adolescent vaccine schedules, members of the Advisory Committee on Immunization Practices voted in favor of recommending the tetravalent meningococcal conjugate vaccine for all 11- to 18-year-olds. This recommendation came after a review of disease epidemiology data showing an increased risk for disease among patients in this age group.



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