Cumulative HIV viremia may predict AIDS-related lymphoma among patients receiving HAART

There may be an independent association between cumulative HIV viremia and risk for lymphoma, according to results of an ongoing German study.

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Researchers analyzed data from 6,022 patients in Germany (involving 27,812 patient-years of follow-up) from the Clinical Surveillance of HIV Disease study. The findings were from patients receiving highly-active antiretroviral therapy (HAART) from 1999 to 2006.

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The HR for lymphoma among patients with cumulative HIV viremia was 1.67 (95% CI, 1.27-2.20).

The association between HIV viremia and lymphoma varied depending on the lymphoma subtype. The HR for Burkitt-type lymphoma among patients with cumulative HIV viremia was 3.45 (95% CI, 1.52-7.85), whereas there was no association observed for central nervous system lymphoma (HR 1.00; 95% CI, 0.39-2.57).

The only risk factors significantly associated with central nervous system lymphoma included age per 10-year increment (HR 1.83; 95% CI, 1.03-3.24) and cell count <200 cells/mcL (HR 6.53; 95% CI, 1.44-29.51).

The researchers conducted multivariate analyses to determine other risk factors for the development of lymphoma among the patients. These results demonstrated that the HR for age per 10-year increment was 1.42 (95% CI, 1.15-1.75), and that the HR for CD4 cell counts of <200 cells/mcL was 8.16 (95% CI, 3.90-17.10).