MRSA is a dangerous pathogen which is difficult to treat due to its ability to develop resistance to antibiotics. In this monograph, the history and epidemiology of community-associated MRSA (CA-MRSA) will be reviewed. Challenges in the development of an effective vaccine and research efforts toward achieving this will be discussed. Three cases of CA-MRSA, presenting as bacteremia, pneumonia, and cellulitis, will be examined. Expert opinions regarding treatments and diagnostic tests to be implemented in each specific case will be presented.