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Back Issues  —  2004

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AROUND THE WORLD
Americas on target to eliminate rubella by 2010 July 2004: Mass vaccination campaigns, a strategy that includes children and adults, and increased surveillance will spell the end of rubella and CRS.
Two children, one adult die from avian influenza in Vietnam September 2004: The government recently announced an initial series of measures aimed at controlling the disease in poultry and preventing further cases in humans.

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BREAKING NEWS & COMMENTARY
Anthrax investigation perks up as FBI conducts searches September 2004: FBI searches homes in New York and New Jersey in relation to its investigation into the anthrax mailings of 2001.
Antifungal given weekly may prevent recurrent yeast infections October 2004: A cure remains elusive, but recurrent bouts were reduced throughout the year.
Asia experiencing worrisome avian flu outbreak; birds being slaughtered February 2004: Health officials have long feared the spread of avian influenza among the susceptible human population.
CDC revises recommendations for treating gonorrhea in MSM July 2004: Increasing cases of fluoroquinolone-resistant gonorrhea prompt shift to new treatment recommendation.
CDC says heterosexual contact cause of 35% of new HIV diagnoses March 2004: Sixty-five percent of women acquire their HIV through heterosexual transmission.
Dialysis possible cause of West Nile virus transmission September 2004: The epidemiologic investigation was inconclusive in determining a source of infection.
Elderly patients may be receiving some inappropriate prescriptions March 2004: Pain relievers and central nervous system drugs make up a large part of the problem.
FDA approves tinidazole for liver abscesses in adults, children July 2004: New drug therapy expected to become an important treatment for trichomoniasis, giardiasis and amebiasis.
FDA investigates Salmonella outbreak linked to tomatoes August 2004: Since July 2, 289 cases of salmonellosis have been reported in Maryland, Ohio, Pennsylvania, Virginia and West Virginia.
GSK awarding $250,000 in research grants July 2004: Applications are now being accepted for the 2004 Drug Discovery and Development Research Grant Program to recognize selected HIV/AIDS researchers working toward breakthroughs.
HAART, prevention could go hand-in-hand to reduce HIV February 2004: A per partnership decline of 60% in risk of becoming infected occurred following the introduction and widespread use of HAART in San Francisco.
Hepatitis B vaccine recommendations to reflect implementation challenges December 2004: First overhaul of the ACIP’s recommendations since 1991 could be published by June 2005.
HHS rolls out smallpox compensation program February 2004: $42 million is earmarked to compensate smallpox volunteers and their contacts who suffered certain adverse events.
IDSA issues new treatment guidelines for community-acquired pneumonia January 2004: The recommendations include specific guidance on choosing antimicrobial therapy.
IDSA releases plan to stimulate antibiotic development August 2004: IDSA recommends government agencies create financial incentives and liability protection to promote antibiotic research.
Influenza vaccine manufacturer expects delays in delivery September 2004: Chiron Corp. officials say that some batches of their vaccine Fluvirin failed to meet sterility requirements.
International guidelines for enfuvirtide established August 2004: Panel publishes recommendations that provide clear framework for optimal use of the fusion inhibitor.
Labs are now top spot to contract SARS-CoV January 2004: WHO expert panel issues biosafety guidelines after a lab worker contracted SARS.
Low efficacy has officials questioning AIDS vaccine October 2004: After failed trials, concerns are raised that significant efficacy will not be shown in an ongoing phase-3 trial of ALVAC plus AIDSVAX.
MRSA shown to have inducible resistance to clindamycin January 2004
MSM practicing safer sex to protect partners from HIV November 2004: MSM with HIV are taking steps to reduce transmission, but some are still practicing risky sexual behaviors.
New antibiotic class approved; first since 1991 May 2004: The FDA gave a thumbs up to telithromycin, the first in a new class of antibiotics called ketolides.
New HIV rapid test receives FDA approval February 2004: Uni-Gold Recombigen HIV has proved safe and effective while also sensitive to HIV antibodies in clinical trials.
N.J. man dies of Lassa fever October 2004: Officials issue health advisory for those who may have been in contact.
Panel sets strains for next year’s influenza vaccine March 2004: The two influenza A strains are set for next year’s vaccine, but the influenza B strain choice remains provisional.
Public health infrastructure is the key to bioterrorism preparedness February 2004: Since 2002, the government has pumped $2 billion into public health preparedness against infectious disease threats, with bioterrorism being just one aspect.
Rabies transmitted from solid-organ transplants July 2004: The CDC is investigating the potential household and health care contacts of the three people who died from the infected organs.
Rare STD spreading among MSM November 2004: Lymphogranuloma venereum is caused by rare strains of C. trachomatis.
Rise in demand may lead to shortage of malaria therapy December 2004: WHO projects a demand of 60 million treatment courses in 2005.
Salmonella osteomyelitis in an immunocompetent patient January 2004: Salmonella infections encompass a wide spectrum of disease.
Smallpox vaccine-associated myopericarditis ‘real entity’ June 2004: Symptoms include chest pain, fatigue, shortness of breath and decreased exercise tolerance, but some patients are asymptomatic.
Traveler’s diarrhea drug approved June 2004: Rifaximin gets nod from FDA to treat traveler’s diarrhea in patients 12 years and older.
Troops are on the front lines against infectious disease threats February 2004: Bioterrorism threats and potential infectious disease outbreaks vary on where deployed military personnel are assigned.
Variant CJD waning, but second wave from transfusions possible November 2004: Blood banks wrestle with balancing risk and safety with public demand and cost.
Variant norovirus linked to gastroenteritis outbreaks in 2002 April 2004
What’s Your Diagnosis?
Wisconsin teen survives rabies infection without vaccine December 2004: Cocktail therapy consisting of coma-inducing drugs and antiviral drugs used in treatment.

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BUSINESS OF PRACTICE
Reducing medical errors requires computerized information systems January 2004: Data standards are crucial to improving patient safety, according to a new report.

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THE DARWIN CHRONICLES
Avian influenza found in Texas March 2004
First mad cow case reported in the United States January 2004: The Darwin Chronicles is a new column featuring news about infections in animals, plants and marine life. Because these organisms sometimes jump species – think BSE and avian flu – we think these stories may be of interest to the ID physician. We hope you enjoy this new monthly feature.

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EMERGING DISEASES
Avian influenza in Vietnam described April 2004: The first reports of the recent avian influenza A (H5N1) outbreak in Vietnam have been published.
Changing paradigms help prepare for emerging diseases October 2004: Enhanced surveillance and better laboratory systems improve response to new disease outbreaks.
Emerging and re-emerging infectious diseases remain a challenge December 2004: Some of the most problematic are SARS, tuberculosis, influenza and malaria.
The history of emerging disease is not that different from its future May 2004: Medical historian Howard Markel, MD, PhD, reflects on why the emerging diseases of the past are important to the future of public health.
IDSA urges Senate to spur anti-infective development November 2004: Physicians support extending Bioshield II to naturally occurring infections.
MRSA infections on a sharp incline among the healthy November 2004: Boils, pneumonia and occasionally necrotizing fasciitis caused by MRSA found to be increasing among healthy people.
Multipronged approach needed to thwart rising resistance rates October 2004: Screening for carriage among hospitalized patients may be needed in addition to contact precautions.
Taking a stand against bad bugs is difficult with no drugs December 2004: The IDSA introduced a plan this year that would stimulate antibiotic development and tackle emerging, drug-resistant bacteria.
West Nile virus studied in transplant patients; cases increase nationally October 2004: West Nile virus illness has been reported to the CDC in 1,865 people from 40 states so far this year.

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GASTROINTESTINAL INFECTIONS
Hepatitis A virus infection and foodborne diseases June 2004: The HAV vaccine has resulted in a decrease in the number of cases of HAV infection in the United States.
New guidelines suggest suppression of HBV viral replication is key April 2004: The HBV treatment algorithm was developed as a practical and comprehensive plan for patients with chronic HBV infection.
Two foodborne outbreaks of HAV: Could they have been prevented? June 2004: HAV transmission could be stymied by universal vaccination.

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HIV/AIDS & STDS
As HAART prolongs lives, HIV-related malignancies appear September 2004: Screening high-risk populations with anal Pap smears may decrease the incidence of disease.
Cluster of HIV identified in N.C. black men who have sex with men May 2004: A study of surveillance data reveals a trend of HIV among black men who attend North Carolina colleges and universities and who have sex with men.
DHHS panel revises antiretroviral use guidelines December 2004: Up-to-date information offers health care providers recommendations for treating adults and adolescents with HIV.
Drug companies, WHO trying to streamline current HIV regimens June 2004: They are working on new antiretrovirals that target different stages of the viral life cycle.
FDA approves first injectable filler for HIV related facial wasting September 2004: Sculptra offers people living with HIV a way to treat lipoatrophy disfigurement caused by some HIV treatments.
FDA approves first oral fluid rapid HIV test April 2004: Before the approval, all rapid HIV tests required the use of blood in order to get 20-minute results.
Federal plan to label condoms comes under fire October 2004: Youth may get mixed messages from certain labels on condoms, according to speaker at the Infectious Diseases Society of America meeting.
Gonorrhea rates decreasing, but antibiotic resistance still a concern December 2004: Dramatic increase in antibiotic-resistant gonorrhea cases prompted shift to new treatment recommendation in MSM this past year.
HIV cases among women increasing around the world December 2004: Approximately half of the 37.2 million adults living with HIV are women, and the numbers are rising, according to a joint UNAIDS/WHO report.
HIV diagnoses increased in more than half of the United States January 2004: New statistics show that more effort in prevention strategies is needed.
HIV drugs in the pipeline offer new hope September 2004: The drugs represent steps forward in the ever-changing world of HIV/AIDS.
HIV in Asia: Act now or pay later, groups warn August 2004: Ten million more Asians may acquire HIV by 2010 unless urgent action is taken now, says report.
HSV vaccine would have significant impact on public health August 2004: Although promising, there is much work to do before vaccine is available, expert says.
Link between smoking, HPV in women with HIV noted June 2004: Increased risk seen regardless of smoking status, but smoking heightens the risk of persistent HPV.
Nevirapine shows resistance but helps prevent mother-to-child transmission March 2004: Research shows that nevirapine still brings mother-to-child HIV transmission rates down, but may cause maternal resistance problems later.
New trends emerge in HIV vaccine development November 2004: Research teams met to share different information, but with the same goal in mind – development of an HIV vaccine.
Number of new HIV infections in NYC women on the rise February 2004: First-year surveillance data reveal the number of people living in New York City who are diagnosed with HIV, not just AIDS.
Primate virus transmitted to people through meat April 2004: It is not known if simian foamy virus is harmful to human beings nor whether it can be transmitted from person to person or through blood transfusions.
Superinfection among couples with HIV questioned August 2004: Study finds no evidence of superinfection, suggests physicians continue promoting serosorting.
Testosterone replacement improves muscle mass in women with HIV July 2004: Little research done in the use of androgens for women with HIV.
Topical microbicides for HIV prevention may be ready in 2013 April 2004: With an HIV vaccine far in the future, topical microbicides have gained favor among researchers hoping to empower women in developing countries.
Trichomoniasis pervasive among high-risk populations May 2004: Metronidazole-resistant trichomoniasis has been reported throughout the United States.
WHO lays out the cards for achieving ‘3 by 5’ January 2004: WHO and UNAIDS want to get 3 million people on antiretroviral treatment by the end of 2005.

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NOSOCOMIAL INFECTIONS
Active surveillance culture issue splits infection control experts August 2004: Active surveillance cultures debated as infection control professionals seek the answer to reducing rising resistance rates.
CDC reports third case of VRSA May 2004: The case appears unrelated epidemiologically to previous cases in Michigan and Pennsylvania.
Endoscopy patients alerted to possible virus exposure August 2004: Lack of documentation forced a N.Y. hospital to notify patients about possible HIV or hepatitis exposure through endoscopes.
Intervention strategies can control spread of CA-MRSA December 2004: The CDC has developed a 12-step program to handle outbreaks.
MRSA incidence on the rise May 2004: MRSA is spreading in tertiary care and community hospitals, regardless of the size of the hospital, and also outside of the hospital.

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RESPIRATORY INFECTIONS
Additional SARS cases reported in China February 2004: A possible animal source, Himalayan palm civets, was being investigated as a cause of infection.
Early treatment for CAP leads to most successful outcomes March 2004: About 80% of cases can be appropriately treated outside the hospital; 20% of patients are usually hospitalized.

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SPECIAL REPORT: CUTANEOUS MANIFESTATIONS
OF HIV DISEASE
Cutaneous manifestations of HIV can predict course of disease April 2004: From Kaposi’s sarcoma to molluscum contagiosum, dermatological disorders present in people with HIV because of their weakened immune systems.

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SPECIAL REPORT: HIV VACCINE UPDATE
Effective HIV vaccine remains wily target March 2004: The first HIV-1 vaccine efficacy trials failed, but they were successful in pointing out areas that need further study.
Physician discusses HIV vaccine ‘plan B’ March 2004: Much progress has been made on the vaccine front, but a plan is needed while work is ongoing.

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SPECIAL REPORT: LINKING VIRUSES & CANCER
Viruses and cancer are linked, but why? February 2004: Some say immune response to infection is the mechanism that turns infectious organisms into cancer.

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SPECIAL REPORT: MALARIA UPDATE
Agreement needed on plan to treat malaria January 2004: There is no official document that outlines how treatment should be handled and funded throughout the world.

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THERAPEUTICS
Ciprofloxacin-cyclosporine interaction: fact or fantasy? June 2004: There is ongoing debate over whether fluoroquinolones, ciprofloxacin particularly, interact with the calcineurin inhibitor cyclosporine.
Not enough antibiotics are in the pipeline May 2004: Out of the 506 drugs currently in development, only five are new antibiotics; a study shows a 56% decline in antibiotic development in 20 years.
Preclinical reports on new antibiotic BAY 73-7388/PTK0796: no cross-resistance June 2004: First compound in a new class of antibiotics shows activity against common infections in early studies.

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TRAVEL MEDICINE
Defining dengue helps doctors make an early diagnosis January 2004: The WHO case definition provides guidance in diagnosing dengue to the practicing clinician who sees many febrile patients.

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VACCINE-PREVENTABLE DISEASES
CDC reports hepatitis B incidence up in certain groups March 2004: Overall incidence has fallen 67%, but the Northeast has seen HBV increase by 41%.
Chiron’s license suspended, U.S. flu vaccine supply cut by half October 2004: Chiron’s 54 million doses of flu vaccine are in limbo after the United Kingdom suspended the supplier’s license for three months.
Fitting FluMist into influenza control July 2004: The new vaccine will undoubtedly play an important role in influenza control.
Flu vaccine shortage highlights need for more vaccine manufacturers November 2004: The ongoing vaccine shortage has cast a spotlight on structural flaws of the troubled vaccine industry.
Flu vaccine shortage may draw attention to waning industry December 2004: The highly publicized influenza vaccine shortage stole the vaccine spotlight this year, but could also bring attention to deeper problems in the industry.
HHS drafts national pandemic influenza preparedness plan September 2004: Increased global influenza vaccine supply and infection control efforts needed in the event of a global pandemic.
HPV 16 vaccine shows effectiveness November 2004
Increasing adult vaccination rate is ‘daunting challenge,’ but attainable July 2004: Adult vaccination rates have gone flat since the early 1990s; much work is needed to reach Healthy People 2010 goals.
New technologies promise more effective future vaccines July 2004: Challenges to vaccines remain, including maintaining political will, but a demonstration of their importance in in the fight against bioterrorism might help.
New vaccine technologies get test run April 2004: New influenza technologies are getting a test run in developing seed lots for an avian influenza vaccine.
Pandemic influenza response planning reaches its stride July 2004: Challenges range from improving surveillance to developing better vaccines.

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