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Back Issues  —  2006

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AROUND THE WORLD
Health officials concerned about possible global spread of XDR-TB November 2006: Extremely drug-resistant TB identified worldwide, especially in Eastern Europe and Asia.
Vancomycin resistance rates vary throughout Europe November 2006: In the 1980s, vancomycin use increased about 50% each year and by 1986 GRE emerged in Europe.
AIDS drugs have saved 3 million years of life in the U.S. July 2006
Global measles deaths fall by nearly half between 1999 and 2004, WHO says April 2006: However, a recent outbreak in Venezuela should serve as a reminder of the importance of vaccinations.
‘Road map’ assists in diagnosing various illnesses in travelers February 2006: Global disease tracking system, GeoSetinel, provides clinicians with surveillance data; significant disease trends are based on region differences.
Yellow outbreaks continue in South America and Subsaharan Africa February 2006: Vaccination and surveillance are key to limiting the spread of the viral disease. Be aware of viscerotropic and neurotropic adverse events.
$30 million grant to create disease control program January 2006: Grant aimed to fund efforts to reduce visceral leishmaniasis, which causes more than 500,000 new cases a year.
Two fixed-dose antimalaria treatments to become available this year January 2006: Drugs offer simplified dosing at a more affordable price compared with current artemisinin-based combination therapies.

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BREAKING NEWS & COMMENTARY
Faster, more accurate tuberculosis test developed December 2006: New test takes an average of seven days to complete and is cheaper and more sensitive than standard culture-based tests.
2006 year in review December 2006
ACIP recommends herpes zoster vaccine for adults aged 60 and older November 2006: Vaccine can help prevent herpes zoster and postherpetic neuralgia in this age group.
IDSA updates Lyme disease recommendations November 2006: The new recommendations are the first updates since 2000.
CDC expects 100 million doses of flu vaccine October 2006: First batches of injectable flu vaccine this year in the United States have been shipped.
FDA warns of E. coli outbreak due to spinach October 2006: Epidemiological and laboratory evidence helped to trace the outbreak to a company in California.
IDSA, SHEA push for strengthened effort for pandemic vaccines September 2006: The two organizations applaud the White House for its efforts but say not enough is being done.
Topical microbicides may be useful in preventing HIV transmission September 2006: Microbicides may be beneficial while researchers continue to work on developing an effective vaccine.
Rapid HIV-test distribution program expands HIV testing in United States August 2006: The Advancing HIV Prevention program distributed tests that provide results in 30 minutes.
Risk-benefit of screening blood supply for malaria unknown August 2006: The FDA convened expert panelists to discuss both sides of the issue.
Measles outbreak stems from Boston's tallest skyscraper July 2006: Fourteen cases of measles are ties to an employee at the John Hancock Tower, which houses about 5,000 workers.
Unsanitary tattooing linked with CA-MRSA skin infections, CDC says July 2006: CDC reports 44 outbreaks of CA-MRSA in Ohio, Kentucky and Vermont associated with 13 unlicensed tattoo artists.
FDA gives herpes zoster vaccine the OK June 2006: The new vaccine will prevent shingles cases among the older population.
New KS-associated herpesvirus receptor facilitates infectivity and dissemination June 2006: KSHV becomes more infectious after inducing a physiological state that results in increased numbers of its xCT, a receptor molecule.
CDC develops guidelines for managing tickborne rickettsial diseases May 2006: Antimicrobial therapy is effective, but early diagnosis is difficult.
Feds release implementation plan for pandemic flu May 2006
FDA advisory committee recommends new indication for IV daptomycin April 2006: Phase-3 data show efficacy of daptomycin to treat patients with S. aureus bacteremia. Committee split on its usefulness to treat infective endocarditis.
HIV subtyping may be useful for management April 2006: People with HIV viral subtype D are more likely to progress to AIDS and die more rapidly compared with people with subtype A.
IDSA calls for more antimicrobial research, development March 2006: IDSA officials identify a target list of six microbes that are in desperate need of new antibiotics.
Mandatory flu shots boost health care worker immunization rate at Virginia Mason March 2006: The CDC recommended universal influenza vaccination for health care workers that suggested signed declination.
FDA announces revisions to prescription drug package inserts February 2006: The FDA adds new selections and updates others while creating new electronic resources for physicians and patients.
FDA cracks down on condom labels February 2006: Label would read: “latex condoms greatly reduce, but do not eliminate the risk of pregnancy and the risk of catching or spreading HIV.”
FDA supports the efficacy and safety of Zostavax January 2006: The vaccine reduced the incidence of postherpetic neuralgia by 66.5%.
HCV population undercounted by 1 million January 2006: The current estimate does not include the incarcerated, homeless, hospitalized, residents of nursing homes and active military.
New HBV treatment shows continued clinical benefit compared with lamivudine January 2006: Thirty percent of entecavir-treated patients came off the drug in the second year of treatment vs. 25% of lamivudine-treated patients.

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DARWIN CHRONICLES
Darwin Chronicles August 2006
Darwin Chronicles July 2006
Darwin Chronicles June 2006
Darwin Chronicles May 2006
Darwin Chronicles April 2006
Darwin Chronicles March 2006
Darwin Chronicles February 2006
Darwin Chronicles January 2006

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EISTORIES
HIV/AIDS – a disease named, research continues August 2006
HIV/AIDS – unfolding cases of an escalating, rare cancer July 2006
HIV/AIDS – the discovery of an unknown, deadly virus June 2006
Legionnaires’ disease – finally, a suspect is found March 2006
Legionnaires’ diseases – narrowing the list of suspects February 2006
Legionnaires’ disease – mounting the first investigation January 2006

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EMERGING DISEASES
Controversies surround treatment of Lyme disease December 2006: IDSA and ILADS disagree on the optimal therapy for patients with Lyme disease.
Know resistance rates in your area to treat CA-MRSA December 2006: CA-MRSA is a ‘moving target,’ according to researcher at AAP.
Norovirus infection may be under-recognized October 2006: Norovirus infections in hospitals may pose a large economic burden on our health care system.
Influenza experts looking closely at Indonesian family with avian influenza June 2006: Even if human-to-human transmission is confirmed, there is no evidence that H5N1 has become an effective transmitter among people.
CDC evaluates eastern equine encephalitis virus outbreak in New Hampshire May 2006: CDC provides prevalence, treatment and prevention options for EEEV.
Emerging resistant fungal infections pose treatment problems April 2006
Pandemic influenza response: Dilemmas of preparedness and equity loom large April 2006: Companies may be able to make 900 million doses of a pandemic influenza vaccine, but there are 6 billion people in the world.
Step up infection control to help stomp out MRSA April 2006: Enhanced surveillance, increased awareness, early detection and appropriate management are needed to control CA-MRSA.

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GASTROINTESTINAL INFECTIONS
C. difficile epidemic continuing to spread September 2006: Strains similar to those in the United States are now showing a presence in Europe.
Entecavir suppresses viral load in patients with chronic hepatitis B July 2006: Phase-3 studies show 94% virologic suppression in HBeAg-negative patients and 30% of lamivudine-refractory HBeAg-positive patients had low viral load.
High HBV rate found among NYC’s Asian community June 2006: The rates are “extraordinarily high” and underscore the need for more intensive screening in this population.

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HIV/AIDS & STDS
Gates grants go a long way December 2006: The Bill & Melinda Gates Foundation focuses on innovations in health and education and provides funding for research efforts.
Gene therapy vector shows promise in fight against HIV December 2006: Lentiviral vectors may be effective for gene transfer to humans, according to phase-1 study results.
HIV positive youth reach out to peers December 2006: NIAID challenges youth to be the generation that ends the AIDS epidemic.
Long road to the development of an effective HIV vaccine November 2006: Vaccine development will require overcoming scientific challenges and attaining basic research in immunology and pathogenesis of the virus.
Multi-drug resistant bacteria increases in hospital settings November 2006: Acinetobacter infections increased from 4.5% in 1995 to 17% in 2004, according to the CDC.
New CDC guidelines for HIV testing will change health care November 2006: New guidelines recommend HIV tests as a regular part of visits to health care providers as well as increased testing in pregnant women.
Pre-exposure prophylaxis a promising HIV prevention tool November 2006: Alternative prevention methods, like PREP, should be further evaluated to help reduce HIV among at-risk groups.
CDC: Test patients for HIV at regular doctor visits October 2006: New recommendations reduce the stigma of HIV testing and increase early HIV diagnosis.
Condoms: the most critical component of the ABC HIV prevention method October 2006: Experts stress that more than catchy slogans are needed to create effective HIV prevention messages.
Decrease in sexual behavior seen among high school students October 2006: Ethnicity plays a role in decline of students engaging in risky sexual behavior.
For patients with AIDS, depression increases with age October 2006: Health care providers should treat patients’ comorbid physical and mental health conditions.
Increasing rates of CA-MRSA occurring among HIV patients October 2006: Risk factors for CA-MRSA in people living with HIV include history of syphilis infection and recent use of beta-lactam antibiotics.
Malnutrition worsens the HIV/AIDS epidemic October 2006: Poor nutrition is associated with significantly poorer survival among HIV/AIDS patients.
Prevention method not as clear as ABC for some September 2006: ABC prevention messages should be clearly defined, consistent and noncontradictory and be combined with other interventions to address barriers in communities.
FDA approves first once-daily, single tablet regimen for HIV August 2006: HIV drug cocktails have reduced the AIDS death rate by 70% in the United States.
Two less frequently recognized STDs common among women August 2006
Risk factors identified for lesser-known STD in MSM July 2006: The CDC has developed a new, accurate, rapid diagnostic test for lymphogranuloma venereum.
Syphilis disproportionately affects MSM June 2006: CDC says syphilis elimination will require new interventions, partnerships and innovations to reach those at risk.
Well-received Internet site warns: ‘you may have contracted HIV or STD’ June 2006: Partner notification system provides MSM with an easy, anonymous way to tell their partners that they may have been exposed.
HIV rates increasing in Tijuana, Mexico May 2006
ARV studied as nPEP and PREP agents to protect against HIV April 2006: Researcher highlights the safety, efficacy and proper administration of post- and pre-exposure prophylaxis for HIV prevention.
Methamphetamine use increases risk of acquiring HIV, STDs and MRSA April 2006: Methamphetamine use is 10% to 20% higher among MSM than in the general population, and 20% to 25% use the drug at least weekly.
AAP provides revised recommendations to reduce adolescent HIV caused by illicit drugs March 2006: Clean needle exchange programs are a proven way to reduce HIV transmission, report says.
Combined chemical and physical barrier methods may reduce HIV transmission March 2006
Length of genital herpes outbreaks decreases with shortened treatment cycle February 2006: Single–day treatment with famciclovir reduced lesions by two days compared with placebo.
NIH ceases enrollment in international HIV/AIDS trial February 2006: SMART trial find that continuous ART is superior to episodic therapy. Risk of disease progression doubled with episodic therapy.
CDC data show stepped up testing and treatment efforts are needed to fight STDs January 2006: Syphilis is increasing in men. Gonorrhea is at an all time low, and chlamydia increased and remains the most commonly reported STD.
Nearly $30 million allocated to microbicide development January 2006: HIV prevention efforts receive support from four European nations.

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IMMUNOCOMPROMISED CONDITIONS
Improved diagnostics may save lives of immunocompromised patients May 2006: There is a lack of inflammatory response in the host, invasive diagnostic procedures are risky and there is a lack of sensitive, minimally invasive assays.

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NEWS NOTES
Research further supports condom use as effective tool against STD transmission July 2006

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NOSOCOMIAL INFECTIONS
Updated isolation precautions near completion September 2006: The revised Healthcare Infection Control Practices Advisory Committee guidelines are slated for release in early 2007. This is the major first revision since 1996.
Transmission of bloodborne infections also occurs in U.S. August 2006: Many people do not realize that bloodborne transmission in the health care setting is not just a problem in the developing world.
C. difficile epidemiology changing, cases and virulence increase May 2006: New drugs in the pipeline address a pressing clinical need: Doctors have been using the same two drugs for 25 years.
Physician paints picture of New Orleans hospital’s response during Hurricane Katrina May 2006: In the middle of the storm, health care workers prepared for the worst and are now faced with the reconstruction stages.

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ON LOCATION
Delivering a message; conference calls for action September 2006: AIDS 2006 brought more than 26,000 attendees to embark on a global response for universal HIV/AIDS treatment access.

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HEALTH POLICY, PATIENT AND PRACTICE ISSUES
Congress hears testimony on pay for performance September 2006: The hearing was for informational purposes and included no votes on legislation.
FDA issues advisory about Ketek and hepatotoxicity February 2006: Pre–marketing data from 25,000–patient safety study indicated that liver problems were infrequent.

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RESPIRATORY INFECTIONS
Avian influenza hits the European Union March 2006: In the U.S., the FDA approved a new laboratory test to detect human avian influenza infections.

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VACCINE-PREVENTABLE DISEASES
HPV vaccine candidate may prevent nearly 80% of cervical cancers December 2006: Mathematical model shows the potential effect of Cervarix, which may offer more protection against cancer causing HPV-types.
Influenza vaccine safe and effective in young infants December 2006: The vaccine was associated with increased antibody responses and no additional safety risks in this patient population.
Mumps outbreak in the Midwest persists August 2006: Vaccine performance and unrecognized importation could have contributed to the high number of cases.
Statins deserve study for treatment and prophylaxis during flu pandemic July 2006: Paper suggests that cholesterol-lowering agents may help lessen the symptoms of influenza.
FDA advisory committee gives green light to Gardasil, Merck’s HPV vaccine June 2006: If the FDA approves this vaccine, pediatricians will be the primary agents responsible for delivering this vaccine to patients.
Health officials trying to halt multistate mumps outbreak May 2006: Iowa health officials offered 25,000 doses of MMR vaccine to people aged 18 to 22.
ACIP recommends Tdap vaccine for health care workers March 2006: The ACIP decided against permissive off-label use of the vaccine among older adults.
Rotavirus vaccine recommended for infants at 2, 4 and 6 months of age March 2006: Premature infants who are clinically stable, at least 6 weeks old and are going to be or have been discharged from the nursery can receive the vaccine.

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